Human Sera
Cayman Chemical BuformInhydrochlorIde 100mg
A biguanide that exhibits antihyperglycemic activity by increasing glucose utilization and inhibiting hepatic gluconeogenesis; inhibits the mitochondrial respiratory complex I and the mitochondrial ATP synthase; disrupts the unfolded protein response transcription program during glucose deprivation, inducing cell death in glucose-deprived tumor cells
Cayman Chemical ClInafloxacInhydroCLOrID 100mg
A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 UG/ml) as well as topoisomerase IV (IC50 = 1.62 UG/ml)
Cayman Chemical N pamylcInamoyl nthrnIl 100mg
A channel blocker that acts on several TRP channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively); inhibits PLA2, blocking the release of arachidonic acid when given at 50 μM
Cayman Chemical DutasterIde 100mg
An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone at 0.045 and 0.756 mg/kg administered as a solution or in subcutaneous microspheres, respectively, daily for 28 days; also decreases prostate weight in a transgenic model of prostate cancer
Cayman Chemical MonacylglycRol lpase InHB 50mg
Selectively and reversibly blocks MAGL activity (IC50s = 0.18 and 59 µM for MAGL and FAAH in mouse brain, respectively); does not inhibit ABHD6, ABHD12, CB1, or CB2 receptors (Kis > 10 µM); used to ameliorate disease progression in a mouse model of multiple sclerosis
Cayman Chemical DntrolensodIum salt 100mg
An inhibitor of sarcoplasmic reticulum calcium release (IC50 = 0.3 µM); binds to sarcoplasmic reticulum vesicles isolated from normal and MHS pigs (Kds = 0.3 and 0.09 µM, respectively); reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes (IC50s = 0.42 and 0.19 µM, respectively); reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 UG/ml) and MHS pigs (ED50 = 0.85 mg/kg)
Cayman Chemical N1AcetylspermInhydrochLR 50mg
A monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine
Cayman Chemical TrIamcInolon acetonIde 100mg
A synthetic corticosteroid; decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model at 1.5 mg/kg administered prior to and following surgery for three days; decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally
Cayman Chemical MItoxntronhydrochlorIde 50mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM
Cayman Chemical PF-04708671 100mg
A specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM); does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity
Cayman Chemical 7-MethylgunosIn 50mg
A methylated form of guanosine; an RNA modification that is present in the 5’-terminal cap of mRNA, as well as in tRNA; has been used as a substrate to measure the activity of PNP; urinary levels are decreased in patients with prostate cancer
Cayman Chemical PF-04708671 50mg
A specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM); does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity
Cayman Chemical PropylhexedrInhydrochLRId 50mg
An α-adrenergic sympathomimetic amine that acts as a local vasoconstrictor; intended for research and forensic applications